Microbial Conversion of Acetanilide to 2′-Hydroxyacetanilide and 4′-Hydroxyacetanilide
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چکیده
منابع مشابه
IUPAC Systematic Name: 4′-Hydroxyacetanilide Synonyms: 4-Acetamidophenol; acetaminophen; 4-acetaminophenol; 4-(acetylamino)- phenol; 4-(N-acetylamino)phenol; 4-hydroxyacetanilide; 4′-hydroxyacetanilide; N-(4- hydroxyphenyl)acetamide
1.1 Chemical and physical data 1.1.1 Nomenclature Chem. Abstr. Serv. Reg. No.: 103-90-2 Deleted CAS Reg. No.: 8055-08-1 Chem. Abstr. Name: N-(4-Hydroxyphenyl)acetamide IUPAC Systematic Name: 4′-Hydroxyacetanilide Synonyms: 4-Acetamidophenol; acetaminophen; 4-acetaminophenol; 4-(acetylamino)phenol; 4-(N-acetylamino)phenol; 4-hydroxyacetanilide; 4′-hydroxyacetanilide; N-(4hydroxyphenyl)acetamide
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We explored, in rats, the conditions underlying the induction of liver tumors by ./V-hydroxy-./V-2-fluorenylacetamide (N-OH-FAA) in terms of the participation of an ultimate carcinogen in the form of the sulfate ester. Male rats were fed 2 dose levels, i.e., 0.0213%(0.89 mmole/kg) and 0.032%(1.34 mmoles/kg) of N-OH-FAA in the diet, with or without 0.89% (59 mmoles/kg) p-hydroxyacetanilide, and ...
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We explored, in rats, the conditions underlying the induction of liver tumors by ./V-hydroxy-./V-2-fluorenylacetamide (N-OH-FAA) in terms of the participation of an ultimate carcinogen in the form of the sulfate ester. Male rats were fed 2 dose levels, i.e., 0.0213%(0.89 mmole/kg) and 0.032%(1.34 mmoles/kg) of N-OH-FAA in the diet, with or without 0.89% (59 mmoles/kg) p-hydroxyacetanilide, and ...
متن کاملImmunochemical comparison of 3'-hydroxyacetanilide and acetaminophen binding in mouse liver.
The hepatotoxicity of the analgesic acetaminophen is believed to be mediated by covalent binding to critical proteins. Radiolabeled 3'-hydroxyacetanilide, a regioisomer of acetaminophen, covalently binds to proteins at levels similar to those of acetaminophen, but without toxicity. Covalent binding has recently been detected by Western blot to a 50-kDa microsomal protein that comigrated with CY...
متن کاملEffect of p-hydroxyacetanilide, sodium sulfate, and L-methionine on the leukemogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide.
Dietary administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide to mice for 14 weeks followed by 16 weeks of control diet resulted in a high incidence of lymphocytic leukemia and a low incidence of forestomach squamous cell papillomas. The coadministration of p-hydroxyacetanilide at a dose of 1.0% with either 250 or 500 ppm of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide resulted in inhi...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1967
ISSN: 0003-6919
DOI: 10.1128/am.15.6.1431-1436.1967